“After the elucidation of the chemical structure of cannabidiol in 1963, the initial studies showed that cannabidiol was unable to mimic the effects of Cannabis. In the 1970’s the number of publications on cannabidiol reached a first peak, having the research focused mainly on the interaction with delta9-THC and its antiepileptic and sedative effects. The following two decades showed lower degree of interest, and the potential therapeutic properties of cannabidiol investigated were mainly the anxiolytic, antipsychotic and on motor diseases effects. The last five years have shown a remarkable increase in publications on cannabidiol mainly stimulated by the discovery of its anti-inflammatory, anti-oxidative and neuroprotective effects. These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson’s disease, Alzheimer’s disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer. Conclusion: In the last 45 years it has been possible to demonstrate that CBD has a wide range of pharmacological effects, many of which being of great therapeutic interest, but still waiting to be confirmed by clinical trials.”
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Antonio W. Zuardi, PhD, Vice Director of the Department of Neurology and Medical Psychology at the University of São Paulo, wrote “Cannabidiol: From an Inactive Cannabinoid to a Drug with Wide Spectrum of Action,” in Revista Brasileira de Psiquiatria:
Teresa Iuvone, PhD, Professor of Experimental Pharmacology at the University of Naples Federico II, et al., wrote “Cannabidiol: a Promising Drug for Neurodegenerative Disorders,” in CNS Neuroscience and Therapeutics:
“The great therapeutic value of CBD, either given alone or in association with THC, derives from the consideration that it represents a rare, if not unique, compound that is capable of affording neuroprotection by the combination of different types of properties (e.g., anti-glutamatergic effects, anti-inflammatory action, and anti-oxidant effects) that almost cover all spectra of neurotoxic mechanisms that operate in neurodegenerative disorders (excitotoxicity, inflammatory events, oxidative injury, etc.).The reported data here, taken together with the evidence of the CBD’s almost absolute absence of side effects, including psychotropicity, suggest its great efficacy and open new horizons for the treatment of the main neurodegenerative disorders!”